The Clear-PEM scanner for positron emission mammography under development is described. The detector is based on pixelized LYSO crystals optically coupled to avalanche photodiodes and readout by a fast low-noise electronic system. A dedicated digital trigger (TGR) and data acquisition (DAQ) system is used for on-line selection of coincidence events with high efficiency, large bandwidth and small dead-time. A specialized gantry allows to perform exams of the breast and of the axilla. In this paper we present results of the measurement of detector modules that integrate the system under construction as well as the imaging performance estimated from Monte Carlo simulated data.

The CMS detector will be upgraded for the HL-LHC to include a MIP Timing Detector (MTD). The MTD will consist of barrel and endcap timing layers, BTL and ETL respectively, providing precision timing of charged particles. The BTL sensors are based on LYSO:Ce scintillation crystals coupled to SiPMs with TOFHIR2 ASICs for the front-end readout. A resolution of 30-60 ps for MIP signals at a rate of 2.5 Mhit/s per channel is expected along the HL-LHC lifetime. We present an overview of the TOFHIR2 requirements and design, simulation results and measurements with TOFHIR2 ASICs. The measurements of TOFHIR2 associated to sensor modules were performed in different test setups using internal test pulses or blue and UV laser pulses emulating the signals expected in the experiment. The measurements show a time resolution of 24 ps initially during Beginning of Operation (BoO) and 58 ps at End of Operation (EoO) conditions, matching well the BTL requirements. We also showed that the time resolution is stable up to the highest expected MIP rate. Extensive radiation tests were performed, both with x-rays and heavy ions, showing that TOFHIR2 is not affected by the radiation environment during the experiment lifetime.