Agradecimentos: The authors are grateful for the financial support provided by the Brazilian public agencies Sao Paulo State Research Foundation (FAPESP, 2018/03571-2 and 2014/50951-4) and CNPq (465768/2014-8 and 301737/2017-7). Scholarships were awarded to P.C.C.A (CAPES), C. R.-S. (CNPq, 154061/2018-2), and A.R.R. (FAPESP, 2018/09697-8). The authors also thank SANASA (Sociedade de Abastecimento de Agua e Saneamento, Campinas, Sao ˜ Paulo, Brazil) for collaboration in this study