Benzodiazepines whose pharmacological properties provide sedative, hypnotic, anxiolytic, anticonvulsant and muscle relaxant actions are the most widely used psychotropic drugs with potential to cause chemical dependence. The objective was to analyze the use of benzodiazepines by medical students and their systemic effects and on the levels of attention, anxiety and school performance, since the sedative and hypnotic effects of this drug are potentiated and may reflect in a depressant action on the System. Central Nervous. This is a descriptive-exploratory and cross-sectional research, in which an electronic questionnaire was applied on the use of psychoactive substances, specifically benzodiazepines, in academics enrolled from the 1st to the 9th period of medicine at a medical school in the south of the State of Tocantins, aged over 18 years, both sexes. Of the 126 responses, 64.3% (81) were female and 35.7% (45) were male. It is observed that the most used drug is clonazepam 0.5mg, followed by alprazolam 0.5mg and in amounts equal to alprazolam 1mg and 2mg, clonazepam 2mg and diazepam 5mg and 10mg. The vulnerability of students at the interface to the mental health scenario has increasingly been in line with anxious and depressive profiles, which were evidenced in the present study. The research found that the use of benzodiazepines by medical students is associated with the strenuous routine of studies and the volume of requirements for preparing a doctor, which evolves to the use of medication after entering college.

The association of severe acute respiratory syndrome 2 (SARS-COV-2) with invasive pulmonary aspergillosis (API) is called CAPA.  Clinical treatment protocols are not described in the world or national literature   resulting in low efficacy and high mortality. The objective was to associate the manifestations of SARS-COV-2 and API, in relation to the diagnostic methods, pulmonary dysfunction   and clinical outcome. The systematic literature review was based on Pubmed, with English descriptors: “aspergilosis”, “covid”, “histology”, boolean "and", with filters: human and published from 2019. 31 articles were identified and 10 were included. The diagnosis for API included research of the Aspergillus galactomannan antigen in serum or sputum, Aspergillus PCR in tracheal aspirate and culture of respiratory samples. The highlighted respiratory compromises are ground-glass opacities, nodular consolidations, bilateral interstitial pulmonary infiltrate, with death as one of the common outcome. CAPA is a co-infection process, future clinical trials are necessary to develop integrated diagnosis, to improve the clinical outcome and minimize mortality.