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  1. 1

    Virchow controversy of an unexpressed triology (I) - causes of venous thrombosis

    Publicação
    por Silveira, Luís
    Origem: Algarve Médico
    The triad, which summarizes the causes of venous thrombosis - vein wall changes, stasis, and hypercoagulability - is attributed to Virchow. This study aims to demonstrate that the triad attributed to Virchow does not belong to him. The father of Anatomopathology published two books that have become famous: “Die Cellularpathologie in ihrer Begrundung auf physiologische und pathologische Gewebelchre” (1839) [Cellular pathology based on physiological and pathological tissue problems] and “Thrombose und embolie“ (1856). However, Virchow studied the genesis of emboli and their effects on pulmonary arteries, trying to contradict the Cruveilhier theory, “phlebitis is the cause of all pathology”, and not the genesis of venous thrombi. This study analyses the items mentioned in Thrombose und Embolie, which have caused this misinterpretation, and in this paper the first of two, after a Historical Introduction, is showed different theories by some scientists who preceded Virchow, such as Wiseman, John Hunter and Cruvelhier, who spoke about the elements of the Triad. Several authors have given many arguments in favour of the role of inflammation of the vein wall and stasis, or both, in the genesis of venous thrombosis. Although none referred to hypercoagulability, some suggested that factors in the blood itself were at the basis of thrombosis. In this first part of the paper, the author covers elements of the history of pathophysiology related to the triad in question.
  2. 2

    Virchow controversy of an unexpressed triology (II): more on venous thrombosis

    Publicação
    por Silveira, Luís
    Origem: Algarve Médico
    This paper extends and conclues the work of an previous publication by the author which reported the elements that conflued to the triad, which summarizes the causes of venous thrombosis - vein wall changes, stasis, and hypercoagulability - attributed to Virchow. In the earlier paper a journey through the history of medicine, was present, with the contributions to an understanding that was being produced in this pathology, the venous thrombosis. This paper focuses exclusively on the domain. This Part 2 of the study aims to demonstrate that the authorship of the triad attributed to him does not belong to Virchow. This study, divided in two papers, analyses the items mentioned in Thrombose und embolie which have caused this misinterpretation, and in this Part 2, shows the theories by Virchow and different theories by others authors, contemporary or later, who have commented on that subject; until it is shown someone who, mistakenly, attributed to Virchow concepts he had never referred to. This study also shows that this professor of anatomopathology denied inflammation and the effect of stasis on the genesis of venous thrombosis, and never mentioned thrombophilia. This article demonstrates that it was not Virchow who mentioned the triad which is mistakenly attributed to him.