The term “medicinal marijuana” can be understood as a marketing strategy to reduce the risk perception of drug use.  The medicinal use of cannabinoids is a debate that has gained importance in this representation space and presents a scientific issue as a scenario to bring the exam. The point of cannabidiol is not new, and its use and efficacy have been controversial. The therapeutic potential has been used as a false argument for the legalization of the use and cultivation of marijuana, with all its compounds. Nowadays, there are no cannabinoids approved for psychiatric indications. The dissemination of scientific information to avoid misperceptions and achieve a clear differentiation among the use of Cannabis in some diseases, in the wellness industry, and the consequences of non-medical use of marijuana should be done. Public policies should be focused on raising awareness about the potentially harmful effects associated with the use of marijuana by the general population. Also, higher investments in scientific research to investigate health damages of the non-medical use of marijuana are needed, as well as a better definition of the health conditions where products derived from Cannabis can be employed as an effective treatment.

This article is a systematic bibliographic review carried out in the period from October 25 to November 4, 2021 through electronic search in the databases of Google Scholar, Science Direct and PUBMED-NCBI-NIH to obtain more recent data, the guiding question of the research was: What is the importance of cannabinoids for the treatment of dermatological physiopathology? The eligibility criteria were selected articles from the last three years concerning cannabis, its cannabinoids and the treatment of dermatological lesions. The descriptors used were: Cannabis, Skin diseases and Cannabinoids verified in Health Science Descriptors (Decs) and Medical Subjec the adings (Mesh). The cross was succeeded using the boolean operator AND: "Cannabis" AND "Skindiseases" AND "Cannabinoids". Nine articles were elected, both analyzed qualitatively, through methodological reading. Even though medicinal herb is known for its psychological use, recent studies show that cannabinoids (Cbs) are actively involved in peripheral systems such as the innate, adaptive immune response. The endocannabinoid system is responsible for regulating several aspects of skin homeostasis such as proliferation, release and differentiation of inflammatory mediators. Therefore, it was possible to observe through the research that Cannabis sativa and its system present in the organism, has large participations for the control of several dermatological and non-dermatological diseases, however, studies are still quite recent and scarce regarding the effect of the herb in the dermatological area, however, already has great advances on its effectiveness.

Introduction. Cannabis-based edibles have become a lucrative and in-demand market. Despite not being legalized in Brazil, marijuana is found in oral preparations illegally marketed in the country and the search for these products has grown in recent years. The present study aims to gather data from the scientific literature on the physiology of the endocannabinoid system, effects of oral cannabis consumption, pharmacokinetics, possible toxic and therapeutic effects and ways of detection, seeking to contribute to filling the gap that still exists on the theme. Methodology. An integrative review was carried out in the PubMed database for publications of the last 5 years in Portuguese, English and Spanish. Results. The search resulted in 128 articles from which the works that did not meet the inclusion criteria were removed, leaving 28 articles used. Conclusions. It is necessary to carry out a greater number of clinical trials with oral cannabis, in the various existing formulations, to better understand its pharmacokinetics, pharmacodynamics, therapeutic potential and its adverse effects.

The WHO (World Health Organization) classifies anxiety as: generalized anxiety disorder, panic disorder, social or specific phobias and social anxiety disorder (SAD). All types share common symptoms, including feelings of malaise, panic and fear, sleep problems, not being able to stay calm, being cold and/or sweating, shortness of breath, heart palpitations, dry mouth, nausea, and prevention of situations, these disorders end up harming the quality of life of many people and often leading to suicide. The aim of the present study was to describe the effectiveness of using cannabidiol for the treatment of anxiety, to describe the physiological mechanisms and its adverse effects. For this, a literature search was carried out through published and current articles where it was possible to analyze its effects on animals and humans, the studies were carried out in a population aged 18-37 years with social anxiety disorder, public speaking phobia and people with post-traumatic disorder caused by childhood trauma. The results showed that cannabidiol can be a powerful option for the treatment of anxiety, its effectiveness in relation to dosage, administration routes and adverse effects showed significant results. The present study demonstrates that more clinical and placebo-controlled studies are needed to demonstrate the effectiveness of cannabis.

The therapeutic properties of Cannabis have been described since antiquity and are of great relevance for the Egyptian, Chinese, Indian, Arab and Latin people. Cannabis-based medicines show several therapeutic purposes, mainly to treat disorders as constipation, some types of pain, epilepsy, anxiety and among others. In addition, the genus Cannabis exhibits great clinical relevance due to its Central Nervous System activities attributed to some phytochemicals compounds, as cannabidiol and Δ9-tetrahydrocannabinol. The interest in the pharmacological properties of Cannabis is growing and several new studies are being carried out to prove its pharmacotherapeutic use which are important to design of novel drugs with different routes of administration and for multiple pathologies resistant to the conventional treatments. In this context, there is a pressure on countries to review the laws that still limit the research development related to medicinal Cannabis purposes. Herein, our aim is to perform an overview about the plant, endocannabinoid system, Cannabis-based medicines and clinical uses, regulatory aspects of Cannabis sp and its chemical compounds of therapeutic interest.

The article reviews the therapeutic and pharmacological effects of cannabidiol, characterizing possible adverse and toxicological effects. This is an integrative bibliographic review carried out in the databases of PubMed, Science Direct and LILACS with the descriptors “drug effects”, “canabidiol” and “treatment” in english, using the Boolean operator AND and restricted to the years 2015 to July 2020. 89 articles were initially found, from the application of the inclusion criteria, it was possible to select the 27 articles constituting the work, from which information about authors, objective, sample, type of research, dosage and result for the composition of results table were obtained. It can be concluded that cannabidiol has therapeutic effects in pathologies related to the central nervous system and the immune system, places where it has mechanisms of action and that intoxication events are not frequently reported, however it has a vast report of adverse effects, in mostly light such as drowsiness and gastric discomfort.

Alzheimer's disease is becoming increasingly common among the elderly, a degenerative, progressive and irreversible neurological disease. The treatment is carried out through drugs with the objective of minimizing the disturbances of the disease and, among the existing pharmacological treatments, those with drugs based on Cannabis sativa stand out. The study aimed to analyze in the scientific literature the therapeutic use of Cannabis sativa in the treatment of Alzheimer's disease. An integrative literature review was carried out, with a qualitative approach, with analyzes carried out online in national journals indexed in the electronic libraries of the following databases: Scientific Electronic Library Online (SciELO); Medical Literature Analysis and Retrieval System Online (Medline); System of Latin American and Caribbean Literature on Health Sciences (LILACS) and Virtual Health Library (VHL). With the data, a record was generated. Among the selected works, only ten presented studies according to the proposed theme. It was observed that the use of Cannabis sativa is effective for the pharmacological treatment of Alzheimer's disease, whose research points to important advantages in its use. It is concluded that research on the advantages of using cannabidiol for therapeutic purposes is essential for the advancement of medicine and for breaking paradigms about Cannabis.

As the population ages, the incidence of some neurodegenerative diseases that affect the functionality of older people increases, such as Alzheimer's disease (AD). It is a progressive neurological pathology characterized by the loss of nerve stimuli from brain neurons. This paper reports the main traits of AD, such as cognitive impairment, and progressive memory loss. However, recently in Brazil, the use of Cannabis herb as a herbal medicine for neurodegenerative diseases has increased considerably, and the challenge of this project is to present the main aspects of the disease, evaluating this new therapeutic alternative, analyzing its metabolic activity through scientific evidence, emphasizing the improvement of the quality of life in the treated patients. The work was produced through a bibliographic research of the integrative literature review type, on the benefits of this compound in the CNS. Thus, at the end of this research, it was possible to assess the relevance of the herb and the impact of these findings on current neurology.

Introduction: Inflammatory Bowel Disease (IBD) are diseases characterized by intestinal inflammation, divided into Crohn's Disease (CD) and Ulcerative Retrocolitis (UC). The cause is still unknown. There are a variety of studies that show the beneficial and potential effect of phytocannabinoids on Inflammatory Bowel Disease. Objective: To evaluate the beneficial effect of Cannabis sativa-derived metabolites in the treatment of IBD, associated with the use of nanotechnology in order to enhance this effect, through a systematic review study. Methodology: This systematic review of the literature of pre-clinical and clinical trials was carried out in the following databases: PUBMED, Science Direct and Scopus from 2012 to 2022. Some combinations of terms were used, such as inflammatory bowel diseases, cannabinoids, cannabidiol and nanotechnology. Results: A total of 418 articles were found in Pubmed, 80 articles in Science Direct and 443 in Scopus. In the end, 6 articles in Pubmed, 10 in Science Direct and 6 in Scopus were considered eligible for analysis according to the established inclusion and exclusion criteria. Discussion: In the analyzed studies, it was noticed that phytocannabinoids represent a promising alternative to treat IBD. Despite the great expectations surrounding these molecules, their physicochemical characteristics represent a significant limitation for their application in the treatment of IBD and other diseases. Therefore, nanotechnology proved to be a way to overcome these problems. Conclusion: In view of all the above, it can be inferred that metabolites derived from Cannabis sativa have great potential for the treatment of inflammatory bowel diseases.

The neurological, chronic and progressive disease known as Parkinson's Syndrome is associated with the constant loss of brain cells that produce the neurotransmitter dopamine, responsible for carrying information to the body. Pharmacotherapy of Parkinson's disease is aimed at controlling symptoms, not completely preventing disease progression; although there is no cure for this syndrome, several palliative treatment methods are available, among them, drug therapy has been shown to be effective. As a healthy and natural alternative, Cannabis sativa shows promising results, especially in cases of chronic pain. Cannabis is among the oldest plants cultivated by man, with archaeological and historical indications; and that the cultivation of the plant was also intended for the extraction of industrial products such as the fibers used in the ropes of boats. Currently, research indicates the therapeutic use of a small number of its active principles with promising results that are being scientifically tested and proven for the treatment of syndromes and/or diseases.